Summary

This tab gives an overview of computed and other annotations available for the query sequence.

Numbering & Regions

If the query sequence has been numbered, this section displays residue numbers and regions for the default numbering scheme and region definitions. Only the numbered section is displayed. See the Numbering & Regions tab for alternative numbering schemes and region definitions. Numbering schemes and region definitions are explained in the help for the About / Defintions page.

The first row of the table shows the residues of the sequence of interest. If DNA is available, a protein/DNA alignment will have been attempted, and the aligned codons will also be displayed.

The second row of the table shows the residues numbers according to the selected numbering scheme. Insertions are highlighted in yellow.

The third row of the table highlights the CDR (loop) regions in red and the framework regions in green.

Unusual residues (residues occuring in less than 1% of all sequences for a given numbered position) are indicated by a vertical arrow. Use the Unusual Residues tab for further information and to analyze frequency in a particular species.

Symbols also indicate potential post-translation modification sites such as N-linked glycosylation sites and phosphorylation sites as well as alerts such as:

Accessions & annotations

A summary of computed and textual annotations is provided. This includes chain classification, human subgroup assignment (where appropriate), warnings, identical sequences, data provenance and references.

Tools

The Blast button transfers the protein and/or DNA sequence into the Blast query page where either sequence can be blasted against various sequence sets in the abYsis database.

If there is a DNA sequence but no protein sequence (for example, if no translation was provided by the Data Source) the Translate & Annotate button will appear. This will transfer the DNA to the Key Annotation Query form where abYsis will attempt to translate and annotate it.

Sequences

The protein and/or DNA sequence will be repeated here in a simple text format that can be cut-and-pasted into other software.