Canonical Classes

CDRs are classified in abYsis using sequence rules which specify loop length and permitted amino acids at required positions. In this way classifications can be made for all numbered sequences, whether or not structural data are available. Use the Region dropdown to select a particular CDR.

Three separate CDR classification methods are implemented within abYsis. These differ in the key residues allowed at different positions. Use the Canonical Method dropdown to select a particular method.

The table shows details of the sequence rules for all the canonical classes corresponding to a particular CDR/method combination.

Chothia position, Permitted amino acids.

For each Method, positions important for a prediction a CDR conformation are listed

The following columns show the permitted amino acids at each required position. These will vary depending on the Canonical Prediction method.

Canonical Prediction Methods

Auto Method

AbM Method

Strict Method

Strict application of templates derived from papers by Chothia et al.

Note